Esha was born in Mumbai on 3rd August 1988 to parents Sushma and Rajan Gupta. Her grandfather, Noor Mohammad Khan, is a renowned poet and writer of Urdu literature. She attended Lawrence School, Sanawar for her primary education and later went on to complete her schooling from The Convent of Jesus and Mary School, Mumbai.
She graduated from National Institute of Dramatic Art with a BA degree in Acting under the guidance of Shlok Sharma. Esha also has a fashion line called "Nayka Couture" which offers affordable men's wear that is designed by her team.